Search results for "Energy based"

Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening

2013

The design through energy-based pharmacophore virtual screening has led to aminocyanopyridine derivatives as efficacious new inhibitors of Hsp90. The synthesized compounds showed a good affinity for the Hsp90 ATP binding site in the competitive binding assay. Moreover, they showed an excellent antiproliferative activity against a large number of human tumor cell lines. Further biological studies on the derivative with the higher EC50 confirmed its specific influence on the cellular pathways involving Hsp90.

Solar Nanoantennas energy based characterization

2016

Solar nanoantennas appear a very interesting solution to exploit solar radiation, as a matter of fact, their operating principle allows heat losses to be lessened compared to traditional photovoltaic cells and efficiency to be increased. Anyway, some technological issues are to be overcome. Literature often proposes a characterization by radiation efficiency typical of traditional antennas. Since the aim of solar nanoantennas is to harvest energy, in this paper the most promising devices are characterized by the upper bound of deliverable power density calculated in the whole operating wavelengths range.

Generalization of Energy-Based Multiaxial Fatigue Criteria to Random Loading

2008